Oral medroxyprogesterone acetate belongs to a class of hormones called progestins. It is used to treat secondary amenorrhea, dysfunctional uterine bleeding (unusual or heavy bleeding of the uterus), endometrial cancer and renal cell cancer.
It is used to oppose endrometrial effects on post menopausal oestregen treatment.
Approved Uses
Treatment of secondary amenorrhea and abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology, such as fibroids or uterine cancer.
Used to reduce the incidence of endometrial hyperplasia in postmenopausal women who have not had a hysterectomy, and who are receiving conjugated estrogen.
Contra-Indications
Any of the following may be reason to choose a different drug. Inform your doctor before starting therapy.
- allergic to medroxyprogesterone or other progestins
- known or suspected pregnancy
- known or suspected breast or genital cancer
- undiagnosed abnormal vaginal bleeding
- active or a history of thrombophlebitis or thromboembolic disorders
- history of stroke
- liver disease
- missed abortion
Dosage and Administration
Dosages may require modification to adjust for individual sensitivities and associated medical conditions.
Adults
Secondary amenorrhea: 5-10 mg per day taken by mouth for 5-10 days, starting anytime, then stop.
Dysfunctional uterine bleeding: 5-10 mg per day taken by mouth for 5-10 days, starting on the 16th or 21st days of the menstrual cycle.
Induction of menstruation: 10 mg per day taken by mouth for 10 days, starting on the 16th day of the menstrual cycle.
Withdrawal bleeding usually starts within 3-7 days after drug is discontinued.
Reduction of endometrial hyperplasia in postmenopausal women taking 0.625 mg conjugated estrogens: 5 or 10 mg taken by mouth daily for 12 to 14 consecutive days per month, beginning on the first day of the cycle or the 16th day of the cycle.
Maximum Dosage Recommendations
Do not exceed the recommended doses, unless deemed necessary by your doctor.
Usual Duration of Use
Allow 2 to 3 menstrual cycles of use to assess the drug's effectiveness.
If You Miss a Dose
Take as soon as possible. If close to the next dose, skip and take the next dose. Do not double the dose.
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