Orlistat, a lipase inhibitor, for weight
maintenance after conventional dieting: a 1-y study.
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Hill JO, Hauptman J, Anderson JW,
Fujioka K, O'Neil PM, Smith DK, Zavoral JH, Aronne LJ
University of Colorado Health
Sciences Center, Denver, USA.
1 : Am J Clin Nutr 1999
Jun;69(6):1108-16
BACKGROUND:
Long-term maintenance of weight
loss remains a therapeutic challenge in obesity treatment.
OBJECTIVE:
This multicenter, double-blind,
placebo-controlled study was designed to test the hypothesis
that orlistat, a gastrointestinal lipase inhibitor, is
significantly more effective than a placebo in preventing
weight regain.
DESIGN:
Obese subjects who lost > or =
8% of their initial body weight during a 6-mo lead-in of a
prescribed hypoenergetic diet (4180-kJ/d deficit) with no
adjunctive pharmacotherapy were randomly assigned to receive
placebo, 30 mg orlistat, 60 mg orlistat, or 120 mg orlistat 3
times daily for 1 y in combination with a maintenance diet to
help prevent weight regain. Of 1313 recruited subjects [body
mass index (in kg/m2): 28-43], 729 subjects lost > or =8%
of their initial body weight during the 6-mo weight-loss
lead-in period and were enrolled in the double-blind phase.
RESULTS:
After 1 y, subjects treated with
120 mg orlistat 3 times daily regained less weight than did
placebo-treated subjects (32.8 4.5% compared with 58.7 5.8%
regain of lost weight; P < 0.001). Moreover, more subjects
in the 120-mg orlistat group than in the placebo group
regained < or = 25% of lost weight (47.5% of subjects
compared with 29.9%). In addition, orlistat treatment (120 mg
3 times daily) was associated with significantly greater
reductions in total and LDL-cholesterol concentrations than
was placebo (P < 0.001).
CONCLUSION:
The use of orlistat during
periods of attempted weight maintenance minimizes weight
readjustment and facilitates long-term improvement in
obesity-related disease risk factors.
Publication Types:
Clinical trial
Multicenter study
Randomized controlled trial
Comments:
Comment in: Am J Clin Nutr 1999
Jun;69(6):1059-60
Comment in: Am J Clin Nutr 1999
Jun;69(6):1061-3
